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Progress and Prospects in Parkinson's Research/Symptoms/O

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The A-Z of Parkinson's Symptoms

O

Oculogyric crises (Attacks of forced deviation of gaze)

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Oculogyric crises

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Attacks of forced deviation of gaze;

The following references are relevant:-

Clough et al (1983) Oculogyric crises and parkinsonism. A case of recent onset [1]

Furumoto et al (1989) Oculogyric crisis as an initial symptom of juvenile parkinsonism-like disease [2]

Wilkaniec et al (2013) Toxicity of extracellular secreted alpha-synuclein: Its role in nitrosative stress and neurodegeneration. [3]

Further Research

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Literature search:

Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- Parkinson's_Disease Oculogyric.
This will list the latest papers on this topic. You are invited to update this page to reflect such recent results, pointing out their significance.
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References

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  1. ↑ Clough, C.G.; Plaitakis, A. and Yahr, M.D. (1983) Full Text Arch. Neurol. 40 (1) 36 - 37. Oculogyric crises and parkinsonism. A case of recent onset.http://www.ncbi.nlm.nih.gov/pubmed/6848086
  2. ↑ Furumoto,H; Kitano, K; Wang, d.s.; Matumoto, S. and Moroo (1989) Full Text Rinsho Shinkeigaku 29 (10) 1287 – 1298 Oculogyric crisis as an initial symptom of juvenile parkinsonism-like disease http://www.ncbi.nlm.nih.gov/pubmed/2605835
  3. ↑ Wilkaniec, A; Stosznajder,J.B. and Adamczyk, A. (2013) Full Text Neurochem. Int. 14. pii: S0197-0186(13)00043-0. Toxicity of extracellular secreted alpha-synuclein: Its role in nitrosative stress and neurodegeneration http://www.ncbi.nlm.nih.gov/pubmed/23416621
Olfactory dysfunction (A reduced or impaired ability to detect odours)

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Olfactory dysfunction

A reduced or impaired ability to detect odors.

The following references are relevant:-

Hoyles and Sharma (2013) Olfactory loss as a supporting feature in the diagnosis of Parkinson's disease: a pragmatic approach[1]

Takeda (2013) Severe olfactory dysfunction is a predictor of dementia with Parkinson’s disease[2]

Hüttenbrink et al (2013) Olfactory dysfunction: common in later life and early warning of neurodegenerative disease [3]

Further Research

Search the scientific literature

Literature search:

Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- Parkinson's_Disease Olfactory_dysfunction.
This will list the latest papers on this topic. You are invited to update this page to reflect such recent results, pointing out their significance.
Pubmed (abstracts)
Pubmed_Central (Full_Text)
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References

  1. ↑ Hoyles, K. and Shama, (2013) Full Text J.C. J. Neurol. (Feb. 3) Olfactory loss as a supporting feature in the diagnosis of Parkinson's disease: a pragmatic approach. http://www.ncbi.nlm.nih.gov/pubmed/23377435
  2. ↑ Takeda,A. (2013) Full Text Rinsho Shinkeigaku 53 (2) 91 – 97 Severe olfactory dysfunction is a predictor of dementia with Parkinson’s disease http://www.ncbi.nlm.nih.gov/pubmed/23470887
  3. ↑ Hüttenbrink. K.B.; Hummel.T.; Berg, D; Gasser, T. and Hähner,A. (2013) Full TextDtsch. Arztebl. Int. 110 (1-2) 1 – 7 Olfactory dysfunction: common in later life and early warning of neurodegenerative disease http://www.ncbi.nlm.nih.gov/pubmed/23450985
'On-off'

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Motor fluctuations

'On-off' periods, wearing off, dose failures, and freezing associated with long-term levodopa use

The following references are relevant:-

Bordelon et al (2011) Medication Responsiveness of Motor Symptoms in a Population-Based Study of Parkinson Disease [1]/

Bohnen et al (2011) Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson’s disease [2]

Mera et al (2012) Feasibility of home-based automated Parkinson’s disease motor assessment [3]

Further Research

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Search the scientific literature

Literature search:

Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- Parkinson's_Disease Motor_fluctuations.
This will list the latest papers on this topic. You are invited to update this page to reflect such recent results, pointing out their significance.
Pubmed (abstracts)
Pubmed_Central (Full_Text)
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References

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  1. ↑ Bordelon, Yvett;M.; Hayes, Ron D,; Vassar, Stefanie D.; Diaz, Natalie; Bronstein, Jeff and Vickrey, Barbra, G. (2011) Full Text Parkinsons Dis. 2001 967839 Medication Responsiveness of Motor Symptoms in a Population-Based Study of Parkinson Disease http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236449
  2. ↑ Bohnen, Nicolaas I.; Muller, Martijn L.T.M.; Zarzhevsky, Natalia; Koeppe, Robert A.; Bogan, Christopher W.; Kilbourn, Michael R.; Frey, Kirk A. and Albin, Roger L.(2011) Full Text Brain 134 (8) 2358 – 2365 Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson’s disease http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155702/
  3. ↑ Mera, Thomas O.; Heldman, Dustin (2012) Full Text J. Neurosci. Methods 203 (1) 152 – 156. Feasibility of home-based automated Parkinson’s disease motor assessment http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221741/
Ophthalmoplegia (Paraylsis of gaze)

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Ophthalmoplegia

Paralysis of gaze.

The following references are relevant:-

Guiloff et al (1980)Reversible supranuclear ophthalmoplegia associated with Parkinsonism [1]

Armstrong (2011)Visual signs and symptoms of progressive supranuclear palsy. [2]


Pontieri et al (2012) Sad and happy facial emotion recognition impairment in progressive supranuclear palsy in comparison with Parkinson's disease[3] Further Research

Search the scientific literature

Literature search:

Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- Parkinson's_Disease Ophthalmoplegia.
This will list the latest papers on this topic. You are invited to update this page to reflect such recent results, pointing out their significance.
Pubmed (abstracts)
Pubmed_Central (Full_Text)
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References

  1. ↑ Guiloff, R.J.; Geirge, R.J. and Marsden, C.D.(1980) Full Text J. Neurol. Neurosurg. Psychiatry. 43 (6) 552 – 554 Reversible supranuclear ophthalmoplegia associated with Parkinsonism http://www.ncbi.nlm.nih.gov/pmc/articles/PMC490600/
  2. ↑ Armstrong, R.A. (2011) Full TextClin. Exp. Optom. 94 (2) 150 – 160 Visual signs and symptoms of progressive supranuclear palsy. http://www.ncbi.nlm.nih.gov/pubmed/20629667
  3. ↑ Pontieri, F.E.; Assogna, F.; Stefani, A.; Pierantozzi, M.; Meco, G.; Benincasa, D.; Colosimo, C.; Caltagirone, C. and Spalletta, G.(2012) AbstractParkinsonism Relat. Disord.18 (7) 871 -875 Sad and happy facial emotion recognition impairment in progressive supranuclear palsy in comparison with Parkinson's disease http://www.ncbi.nlm.nih.gov/pubmed/22595619
Orthostatic hypotension (Drop in blood pressure during changes in body position)

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Orthostatic hypotension

Drop in blood pressure during changes in body position.

A recent review of Cardiovascular dysautonomia in Parkinson's by Jain and Goldstein (2012) is particularly relevant.[1]

The following references are also relevant:-

Hussain et al (2001) Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson's disease or multiple system atrophy with observations on orthostatic hypotension [2]

Park and Stacy(2011) Dopamine-Induced Nonmotor Symptoms of Parkinson's Disease [3]

Sommer et al (2011) Nondipping in Parkinson's Disease [4]

Further Research

Search the scientific literature

Literature search:

Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- Parkinson's_Disease Orthostatic_hypotension.
This will list the latest papers on this topic. You are invited to update this page to reflect such recent results, pointing out their significance.
Pubmed (abstracts)
Pubmed_Central (Full_Text)
Google_Scholar


References

  1. ↑ Jain, Samay, and David S. Goldstein. Cardiovascular Dysautonomia in Parkinson Disease: From Pathophysiology to Pathogenesis. Neurobiology of Disease 46, no. 3 (June 2012): 572–580. Full Text PubMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299874/
  2. ↑ Husain, I.; Brady, C.; Swinn, M.; Mathias, C. and Fowler, C. (2001) Full TextJ. Neurol. Neurosurg. Psychiatry. 71 (3) 371 – 374 Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson's disease or multiple system atrophy with observations on orthostatic hypotension http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1737541/
  3. ↑ Park, Ariane and Stacy, Mark(2011) Full TextParkinsons Dis. 2011 485063. Dopamine-Induced Nonmotor Symptoms of Parkinson's Diseasehttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096061/
  4. ↑ Sommer, Sita: Aral-Bexhwe, Billur and Jost, Wolfgang (2011) Full TextParkinsons Dis. 2011: 897586. Nondipping in Parkinson's Disease http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175384/

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Links to the symptoms of Parkinson's in alphabetical order:

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