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Biophysics/Introduction

< Biophysics

Biophysics Projects

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Welcome to the Biophysics Project and the Department of Biophysics!

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Soliton Wave animation by Dr. Danko Georgiev
 
Biophysics Course


Département de Biophysique

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  • "Cette discipline aboutit à l'utilisation de moyens modernes d'investigation qualitatifs et quantitatifs en Biologie comme en Médecine, ainsi que, dans cette dernière, à des moyens thérapeutiques à partir de l'utilisation notamment des ondes et radiations."

"La biophysique est l'étude des phénomènes physiques intervenant chez les êtres vivants."

Faculté de Biologie

Département de Biologie Moléculaire

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"La biologie moléculaire est une discipline scientifique au croisement de la génétique, de la biochimie et de la physique, dont l'objet est la compréhension des mécanismes de fonctionnement de la cellule au niveau moléculaire. La biochimie est la discipline scientifique qui étudie les réactions chimiques ayant lieu au sein des cellules."

Languages: (en),(fr), (ro)

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"Biophysics is the study of physical phenomena that occur in living beings"... , but without a definition of Life, or of the "living", the subject of Biophysics would remain only vaguely pointing at functional organisms. Determining what Life is also remains, therefore, in the domain of Biophysics--specifically of Mathematical biophysics or Relational Biology. In other words, one is asking:
What are the fundamental relations among the components and processes, and also <relations> among relations occurring in an organism that distinguish the latter from a simple or complex physical system, such as a crystal, a stone, a machine or automaton, a robot, a computer, and so on ?
A related question is that of the underlying operational logics of an organism (which is not Boolean, and it is not perhaps even a quantum logic), and of its defining axioms.

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Welcome to an International Biophysics Course !

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  • Lecture notes can be now obtained in: English (en), French (fr) and Romanian (ro), (ISO 691-1) languages.
  • New instructors or students may add, however, more languages-- among those already approved by the Wikiversity for such educational and research web site projects.
  • The addition to this website of specialized expert new lectures or lecture notes or web links to Lecture notes and other Biophysics or Crystallography departments-- that fit in with the announced Syllabus-- is encouraged and appreciated.
  • For questions regarding Ph.D. review questions in Crystallography see also Doctoral review questions in Crystallography
  •  
    DNA Double-helix Molecular Model

Syllabus

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  • Protein and Nucleic Acid Structure and Dynamics:

Up-to-date descriptions of the background, methods and techniques of protein crystallography, including the mathematical concepts and tools needed to understand X-ray and neutron diffraction, as well as 2D-FT NMR determination of molecular structure in solution. (See also a simple introduction to Proton (H-1) NMR (fr))

Protein crystallography is a multidisciplinary area of research that overlaps in part with several subfields of biochemistry, structural molecular biology, bioinformatics, biophysics, biochemistry and organic chemistry.
 
XRD Structure Determination Steps

Lecture 15:Examples of crystal lattices: fcc, bcc, diamond; Miller indices of crystal lattice planes.

 
A- and B- DNA X-ray Diffraction Patterns compared
  • Mathematical Foundations of Biophysics:
    • Computational biophysics: Molecular Dynamics and computer simulation techniques (e.g., Monte Carlo)
    • Mathematical Foundations of Quantum Biophysics and Quantum Biochemistry
    • Harmonic analysis in Medical Diagnostic Imaging and Patient image processing, contrast enhancement or reconstruction
    • Modelling cells and multicellular organisms
    • Biotopology and Algebraic Topology applications to Mathematical Biophysics
    • Relational Networks and Categories of Metabolic-Replication Systems
    • Relational Biology applications to understanding Aging and Metabolic Disorders


 
 

Wikiversity Topic:Photosynthesis
The Lessons in the
Photosynthetic Mechanisms ORIENTATION

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    Photosynthesis in the Biosphere



  • Syllabus of an International Course on Photosynthesis
 
Overall Chemical Reactions for Plant Photosynthesis
    • Structure and Dynamics of Photosynthetic Membranes
    • Quantum mechanisms of photosynthetic water oxidation in algae and higher plants
    • Mechanisms of PS I photosystem
    • Manganese and calcium ion role(s) in photosynthetic water oxidation
    • The Oxygen Evolving Complex: Structure and Function
    • FCS applications to Photosynthesis
    • Single Molecule Detection and Femtosecond Laser Spectroscopy studies of Photosynthesis
    • High-field and 2D-NMR investigations of Photosynthetic Mechanisms
    • FT-NIR Spectroscopy and Hyper-spectral/Chemical Imaging of Photosynthetic Cells and Functional Chloroplasts

Learning materials and introductory articles

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Carbon Fixation and Photorespiration in Plants
  1. w:C4 carbon fixation: trace experiments with radioactive labels
  2. Quantum physics aspects of w:Photosynthesis
  3. Photosynthetic systems: w:PSI and w:PSII coupling
  4. w:aquaporin
  5. Specific w:chloride channels
  6. w:Hydronium ion
  7. Specific w:Hydronium ion
  8. Beta counting
    1. w:Regulation of metabolic pathways
  9. Specific inhibitors of photosynthesis, such as hydroxylamine (NH2OH) and uncouplers
    1. Gas chromatography and mass spectrometry
    2. Gamma counting
    3. w:Enzyme assays
    4. w:Micronutrients
      1. Manganese ions' role(s) in photosynthesis
        1. Neutron activation analysis of Mn contents in purified, active thylakoid (photosynthetic) membranes and PSII-particles
    5. w:Enzymes
    6. Krebs' cycle
    7. w:Pyruvate decarboxylation
    8. The ATP cycle and its coupling to photosynthetic processes
    9. w:Oxidative phosphorilation
    10. w:Calvin Cycle
    11. Dickens-Horecker cycle
    12. Hexose interconversions
    13. w:Neoglucogenesis
    14. w:Glycogenesis
    15. w:Glycogenolysis
    16. w:Cori cycle
    17. w:fatty acids
    18. Essential fatty acids
      1. poly-unsaturated fatty acids (w:PUFA);
      2. w:eicosanoids: w:prostaglandins, w:thromboxanes, w:prostacyclin and w:leukotrienes.
    19. The w:lipid bilayer, item, and transport across the bilayer through pores, channels, etc.
    20. w:PCR

Selected Examples

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Solutions of the Bessel differential equation.
  1. Bessel functions arise in many mathematical models such as those for vibrating surfaces. Such functions also occur in the analysis of X-ray Diffraction patterns of helical molecules such as certain proteins and also nucleic acids (DNAs, RNAs.)

"When mathematically analyzing a vibrating drum the boundary conditions lead to solutions that are harmonic functions. When using cylindrical coordinates, the solutions are sines, cosines or Bessel functions (in the radial direction)".


Notes

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  • Presentation = Présentation sur Protéines

"Protéine, macromolécule composée d'acides aminés reliés par des liaisons peptidiques, présente chez les organismes vivants et essentielle à leur fonctionnement. Découvertes en 1838, les protéines sont le principal composant des cellules, représentant plus de 50 p. 100 de leur poids sec. Le mot protéine vient du grec proteios qui signifie « premier ».

La forme des protéines est très variable : elle va des longues fibres présentes dans les tissus conjonctifs et les cheveux aux globules compacts et solubles capables de traverser la membrane des cellules. Les protéines sont des macromolécules dont le poids moléculaire varie de quelques milliers à plus d'un million d'unités. Elles sont spécifiques à chaque espèce vivante et à chaque organe. On estime qu'il existe environ trente mille protéines différentes chez l'Homme, dont 2 p. 100 seulement ont été décrites. Les protéines servent à construire et à entretenir les cellules, et leur dégradation chimique fournit de l'énergie, produisant près de 4 kilocalories par gramme (voir Métabolisme).

Outre leur rôle dans la croissance et l'entretien des cellules, les protéines sont également responsables de la contraction des muscles. Les enzymes digestives sont des protéines, de même que l'insuline et la plupart des autres hormones, ainsi que les anticorps du système immunitaire et l'hémoglobine. Les chromosomes, qui transmettent toutes les caractéristiques héréditaires sous forme de gènes, sont constitués d'acides nucléiques et de protéines (histones).

Course textbooks

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Things remaining to do-Short list

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  1. Continue and expand lectures
  2. New Instructor involvement in biophysics courses
  3. Web links to biophysics and protein structure syllabi at several universities
  4. Add other resources (such as: Structure and Genomic Databases, Image libraries and galleries, Library links, and so on.
  5. Develop student Enrollment and student Help pages

See also

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                      • ==Lectures (en), (fr),(ro)==

Leçons par thèmes = Lectures by subject

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  • Données de physique utilisées en biologie [Modifier]

Leçons par niveau = Lectures by level

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  • Novice Niveau 0 à 2 Débutant Niveau 2 à 5 Intermédiaire Niveau 6 à 9
  • Avancé Niveau 10 à 12
    • Données de physique utilisées en biologie
  • Expert Niveau 13 à 15
    • Ondes et optique géométrique
  • Perfectionnement Niveau 16 à 18
    • Modèle:2--Microspéctroscopie et Analyse Biochimique des Images d'Embryon. Modifier!

Instructors

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If you have knowledge in this field, please post your name here to answer questions from students.

Short list of course consultants and instructors:

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  • User:Bci21- Instructor & Professor-Professeur
  • Biophysik
  • Y
  • Z
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  • Basics
    1. The International System of Units, item
    2. Nomenclature of organic chemistry,item,
    3. w:Logarithms
    4. w:Nuclides
    5. w:Radioactive decay
    6. w:gas laws, Gases and Gas Laws
    7. w:Partial pressure and w:mole fraction
    8. w:Osmosis
    9. w:Diffusion
    10. pH, pKa's and titration
    11. Buffers
  • Biomolecules -- Structures, classification and properties of:
    1. w:Nucleic acids
    2. w:Amino acids
    3. w:Protein
    4. w:Carbohydrate
    5. w:Lipid
  • Laboratory and Analytical Methods
    1. Simple (glass) laboratory equipment and how to use it
    2. Laboratory safety
    3. w:Size exclusion chromatography
    4. UV-VIS Spectrometry
    5. Centrifugation and w:Ultracentrifugation
    6. w:Electrophoresis
    7. w:Chromatography
    • Amino acids
      1. w:Decarboxylation
      2. w:Transamination
      3. General amino acid synthesis
      4. General amino acid catabolism
      5. Special amino acid metabolism
      6. Amino acid interconversion
      7. w:Urea cycle, item
      8. Gamma-glutamyl cycle
      9. Associated: w:Gout,w:Maple syrup disease
    • Proteins
      1. In vivo nucleic acids synthesis
      2. Nucleic acid degradation, pyrimidine and purine catabolism
      3. w:Peptide bond
      4. In vivo protein synthesis

References

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Virtual Labs

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Virtual Molecular Biology and Biophysics laboratories
 
Ion Trap in a Mass Spectrometer

(Schéma d'un analyseur de type trappe ionique (pièges à ions) 3D et trajectoire des ions, en spectrométrie de mass).

 
NMR spectrometer
 
COSY 2D-NMR Spectrum
 
2D-FT (N)MRI Imager
 
Triple Quadropole Mass Spectrometer
 
Synchrotron SOLEIL facility near Paris
 
ISIS Pulsed neutron facility hall
 
SLAC Synchrotron entrance near Stanford, CA
 
SLAC Detector

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