Talk:WikiJournal Preprints/CARD-CC family
This article is an unpublished pre-print undergoing public peer review organised by the WikiJournal of Science.
It is adapted from the Wikipedia page CARD-CC family. It contains some or all of that page's content licensed under a Creative Commons Attribution ShareAlike License and will also be used to update that article after peer review.You can follow its progress through the peer review process at this tracking page.First submitted:
Article text
QID: Q116768204
Suggested (provisional) preprint citation format:
Jens Staal. "CARD-CC family". WikiJournal Preprints. Wikidata Q116768204.
License: 
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction, provided the original author and source are credited.
Henry Hoff 
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Daniel Krappmann
Article information
This is the pre-publication public peer review for the article CARD-CC family
Plagiarism check
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Pass. Report from WMF copyvios tool: only trivial overleap with other sources such as "and motor proteins, and transcription factors". T.Shafee(Evo﹠Evo)talk 22:46, 8 February 2023 (UTC)
Editorial comments
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Comments by Andrew Leung 
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These editorial comments were submitted on , and refer to this previous version of the article
Similar to WikiJournal Preprints/MALT1, I would like to see the following points to be improved before sending it to peer reviewers:
- The evolution and species distribution covered the history aspect from an evolutionary perspective. It should provide a brief history on how it was discovered (and by whom). See WikiJournal of Medicine/A history of coronaviruses for example.
- The bullet-point sentences in "Functions" section should be organized into paragraphs based on commons themes.
Again, you can take a look at WikiJournal of Science/RIG-I like receptors and WikiJournal of Science/The TIM barrel fold as examples.
Peer review 1
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Review by Daniel Krappmann , Helmholtz Zentrum München
These assessment comments were submitted on , and refer to this previous version of the article
The summary on CARD-CC looks good and should be informative to the readers. As I don’t have much time to edit online or so, I simply suggest to add something to the section on function:
… CBM complex assembly results in recruitment of TRAF6 to MALT1 and downstream activation of NF-κB transcriptional activity and expression of pro-inflammatory cytokines (REF1). In addition, CBM complex formation activates MALT1 protease function, which modulates immune and inflammatory responses (REF2). The different CARD-CC family…
I would add these Refs for clarity:
REF1: O’Neill, T.J., T. Seeholzer, A. Gewies, T. Gehring, F. Giesert, I. Hamp, C. Graß, H. Schmidt, K. Kriegsmann, M.J. Tofaute, K. Demski, T. Poth, M. Rosenbaum, T. Schnalzger, J. Ruland, M. Göttlicher, M. Kriegsmann, R. Naumann, V. Heissmeyer, O. Plettenburg, W. Wurst, and D. Krappmann, TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease. Science Immunology, 2021. 6(65): p. eabh2095. DOI: 10.1126/sciimmunol.abh2095.
REF2: Jaworski, M. and M. Thome, The paracaspase MALT1: biological function and potential for therapeutic inhibition. Cell Mol Life Sci, 2016. 73(3): p. 459-73. DOI: 10.1007/s00018-015-2059-z.