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VOLUME 5 (2018)
ISSUE 1
Current issue
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Authors: Alison Cheong, Sean McGrath, Suzanne Cutts
Anthracyclines are a clinically important class of antineoplastic agents used to treat a wide variety of solid and blood cancers. The first described anthracycline, daunorubicin, was first isolated from a strain of Streptomyces peucetius in the early 1960s. Clinically the most widely used are doxorubicin, daunorubicin and their semi-synthetic derivatives epirubicin and idarubicin. They primarily act by intercalating with DNA and inhibiting topoisomerase II, resulting in DNA breaks and abrogated DNA synthesis. The most serious side effect of anthracycline use is cumulative dose-dependent cardiotoxicity, limiting recommended maximum lifetime treatment to 400-450 mg/m2. Several liposomal formulations of doxorubicin are in use, having the benefits of prolonging retention rate while reducing peak plasma concentration of free drug. Several clinical trials of anthracycline-loaded nanoparticles are currently underway.
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VOLUME 4 (2017)
ISSUE 1
Previous issue
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Authors: Aaron Smith, Michael AF Parkes, Georgia K Atkin-Smith, Rochelle Tixeira, Ivan KH Poon
The disassembly of a dying cell into smaller fragments is a fundamental biological process during apoptosis. Recently, a number of distinct morphologic changes have been identified that could mediate the fragmentation of an apoptotic cell. Presented here is a figure that describes the progression of apoptotic cell disassembly.
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Authors: Graham Beards, et al.
Rotavirus is the most common cause of diarrhoeal disease among infants and young children. It is a genus of double-stranded RNA viruses in the family Reoviridae. Nearly every child in the world is infected with rotavirus at least once by the age of five. Immunity develops with each infection, so subsequent infections are less severe; adults are rarely affected. There are eight species of this virus, referred to as A, B, C, D, E, F, G and H. Rotavirus A, the most common species, causes more than 90% of rotavirus infections in humans.
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Authors: Michaël R. Laurent , Lode Van Overbeke
Gastrointestinal bleeding (GI bleed) is a common and potentially life-threatening reason for emergency room and intensive care unit admission. This article reports the case of an 83-year-old man with acute GI bleeding from an unusual cause. The clinical information is presented in a step-by-step and question-answer format for learning purposes. This paper is particularly aimed at an internal medicine readership.
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Authors: Soumyadeep Bhaumik, Zohra Lassi
Pneumonia is the most important cause of death in children under five years old. Vitamin D is cheap and known to improve the immune system response against respiratory diseases such as tuberculosis. This meta-analysis found three randomized placebo-controlled trials of vitamin D as an additional treatment for pneumonia in 997 infants and children. Taken together, these trials showed no effect of vitamin D cure rates, mortality, time to clinical recovery or duration of hospital stay for pneumonia in children. The quality of evidence is however still low.
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Authors: Kholhring Lalchhandama
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Authors: Marion Wright, et al.
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Authors: Thomas Shafee, Rohan Lowe
Genes consist of multiple sequence elements that together encode the functional product and regulate its expression. Despite their fundamental importance, there are few freely available diagrams of gene structure. Presented here are two figures that summarise the different structures found in eukaryotic and prokaryotic genes. Common gene structural elements are colour-coded by their function in regulation, transcription, or translation.
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Authors: Thomas Shafee, Diptanshu Das, Gwinyai Masukume, Mikael Häggström
WikiJournal of Medicine is an open access, peer reviewed journal free of publication charges for its authors. It publishes both original research and reviews. It was created in 2014 and has grown rapidly since then. This editorial will highlight its unique features and the developments seen in 2016.
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