Progress and Prospects in Parkinson's Research/Therapy/Neuroprotection/DHA

DHA offers pointers to new potential forms of neuroprotection.

Background

DHA or Docoaheaenoic acid is an omega-3 fatty acid that is a primary structural component of the human brain, sperm, testicles and retina.

Research

2003

Wang et al tested the effects of DHA on rats. They found:-

DHA at 5-50 microg/ml successfully protected neurons against the cytotoxicity, markedly increased the cell viability, inhibited both nitric oxide (NO) production and calcium influx, and increased the activities of antioxidant enzymes of glutathione peroxidase (GSH-Px) and glutathione reductase (GR).

2006

Samadi et al tested the effect of the application of DHA to monkeys treated with MPTP to induce levadopa-induced dyskinesia (LID). Their findings were that :-

These results suggest that DHA can reduce the severity or delay the development of LIDs in a nonhuman primate model of Parkinson's disease.

2008

Cansey et al worked with rats rendered Parkinsonian by the administration of 6-OHDA. They were then treated with uridine-5’-monophosphate (UMP) and docosahexaenoic acid (DHA).

Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 days after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and Synapsin-1 on the lesioned side. Hence, giving uridine and DHA may partially restore dopaminergic neurotransmission in this model of Parkinson’s Disease.

Bousquet et al tested the hypothesis that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may exert neuroprotective action in Parkinson's disease, by putting mice on a high PUFA diet and then inducing Parkunsonism with MPTP.

The result was a mix of good and bad news but there was sufficient of the former to warrant the conclusion:-

Taken together, these data suggest that a high n-3 PUFA dietary intake exerts neuroprotective actions in an animal model of Parkinsonism.

2011

Ozsoy et al tested the effect of DHA application on MPTP treated mice . They found that:-

• Docosahexaenoic acid significantly diminished the amount of cell death in the MPTP+DHA group as compared to the MPTP group.

• TBARS levels in the brain were significantly increased following MPTP treatment.

• Glutathione_peroxidase (GPx) and catalase (CAT) activities of brain were unaltered in all groups.

• The activity of brain superoxide dismutase (SOD) was decreased in the MPTP-treated group compared to the control group,

• but DHA treatment did not have an effect on SOD activity in the MPTP+DHA group.

Further Reading

2008

Liu, Xuebo; Shibata, Takahiro; Hisaka, Shinsuke; Kawai, Yoshichika and Osawa, Toshihiko. Full Text J. Clin. Biochem. Nutr. 43 (1): 26–33.

DHA Hydroperoxides as a Potential Inducer of Neuronal Cell Death: a Mitochondrial Dysfunction-Mediated Pathway

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2459249/?tool=pmcentrez

Liu, Xuebo; Yamada, Naruomi; Maruyama, Wakako and Osawa, Toshihiko. Full Text J. Biol. Chem. 283 (50): 34887 – 34895.

Formation of Dopamine Adducts Derived from Brain Polyunsaturated Fatty Acids.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259879/?tool=pmcentrez

2011

Bousquet, Melanie;Gue, Karl; Emond, Vincent; Julien, Pierre; Kang,Jing X.; Cicchetti, Francesca and Calon, Frederic. Full Text J. Lipid Res. 52 (2): 263–271.

Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023546/?tool=pmcentrez

2012

Kim, Kiyoung; Kim,Song Hee; Kim, Jackwang; Kim, Heuijong and Yim, Jeingbin.Full Text J. Biol. Chem. 287 (9): 6628 – 6641.

Glutathione S-Transferase Omega 1 Activity Is Sufficient to Suppress Neurodegeneration in a Drosophila Model of Parkinson Disease

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307323/?tool=pmcentrez

Today

Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- Parkinson's_Disease DHA.

This will list the latest papers on this topic. You are invited to update this page to reflect such recent results, pointing out their significance.

Pubmed (abstracts)

Pubmed_Central (Full_Text)

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Related pages

Therapy > Neuroprotection

Sub Pages:

Neuroprotective agents

Substances with possible neuroprotective properties:

Caffeine,--Celastrol,--Co-Enzyme Q10,--Creatine,--DHA,--Exendin-4 (EX-4),--GDNF,--Glutathione (GSH),--GM1,--Isradipine,--Melatonin,--Minocycline,--Nicotine,--NSAIDs,--Phenylbutyrate,--Phytic Acid,--Probucol,--Quinoxaline,--Rasagiline,--Riboflavin,--Statins,--Tolcapone,--Urate & Uric Acid,--Vitamin D,--Vitamin E,--

References

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