Progress and Prospects in Parkinson's Research/Therapy/Neuroprotection/Riboflavin

Uncorroborated research has found that PD patients are deficient in riboflavin and it is hypothesised that its replacement could confer neuroprotection.

Background edit

Riboflavin also known as Vitamin B2 is a vital dietary component that is found in dairy foods, yeast, fresh vegetables and offal. It has a role in the metabolism of fats, carbohydrates and proteins.

Research edit


Coimbra and Junqueira [1] detected riboflavin deficiency in 31 consecutive PD outpatients. 25 patients were given enhanced doses of riboflavin for 6 months and they cut red meat from their diet.

At the end of the experiment their mobility rating had increased from 44% to 71%

Further Reading edit


January Neurotalk Full Text

Riboflavin benefits Parkinson’s patients

This article discusses the implications of the work of Coimbra and Junqueira.


Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- Parkinson's_Disease Riboflavin.

This will list the latest papers on this topic. You are invited to update this page to reflect such recent results, pointing out their significance.

Pubmed (abstracts)

Pubmed_Central (Full_Text)


Related pages edit

Therapy > Neuroprotection

Sub Pages:

Neuroprotective agents
Substances with possible neuroprotective properties:
Caffeine,--Celastrol,--Co-Enzyme Q10,--Creatine,--DHA,--Exendin-4 (EX-4),--GDNF,--Glutathione (GSH),--GM1,--Isradipine,--Melatonin,--Minocycline,--Nicotine,--NSAIDs,--Phenylbutyrate,--Phytic Acid,--Probucol,--Quinoxaline,--Rasagiline,--Riboflavin,--Statins,--Tolcapone,--Urate & Uric Acid,--Vitamin D,--Vitamin E,--

References edit

  1. Coimbra, C. G. and Junqueira, V. B. {2003)(2003)Abstract Braz J. Med. Biol. Res. 36(10):1409 - 1417. High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson's disease patients.