Portal:Structural biology

Welcome to the Department of Structural Biology!


Hello and Welcome to Wikiversity Structural biology! You can contact us with questions at the colloquium or me personally when you need help. Please remember to sign and date your finished comments when participating in discussions. The signature icon OOUI JS signature icon LTR.svg above the edit window makes it simple. All users are expected to abide by our Privacy, Civility, and the Terms of Use policies while at Wikiversity.

To get started, you may

You do not need to be an educator to edit. You only need to be bold to contribute and to experiment with the sandbox or your userpage. See you around Wikiversity! --~~~~

Structural biology is a branch of molecular biology concerned with the study of the architecture and shape of biological macromolecules—proteins and nucleic acids in particular—and what causes them to have the structures they have. This subject is of great interest to biologists, because macromolecules carry out most of the functions of a cell, and because typically it only is by coiling into a specific three-dimensional shape that they are able to perform their functions. This shape, which is called the "tertiary structure" of a molecule, depends in a complicated way on the molecule's basic composition, or "primary structure."

Biomolecules are too small to see in detail even with the most advanced light microscopes. The methods that structural biologists use to determine their structures generally involve measurements on vast numbers of identical molecules at the same time. These methods include crystallography, NMR, ultra fast laser spectroscopy, electron microscopy, electron cryomicroscopy (cryo-EM), and circular dichroism. Most often researchers use them to study the static "native states" of macromolecules. But variations on these methods are also used to watch nascent or denatured molecules assume or reassume their native states (see e.g. protein folding).

A third approach that structural biologists take to understanding structure is bioinformatics to look for patterns among the diverse sequences that give rise to particular shapes. Researchers often can deduce aspects of the structure of integral membrane proteins based on the membrane topology predicted by hydrophobicity analysis. See: protein structure prediction.

In the past few years it has become possible for highly accurate physical molecular models to complement the in silico study of biological structures. Rapid prototyping technologies such as those used by 3D Molecular Design, or the creation of molecular models in glass by Luminorum Ltd, are notable examples of recent advances in this field.

Department newsEdit

  • February 28, 2007 - Department founded!

Learning projectsEdit


Active participantsEdit

Wikibook textbooksEdit

The Structure of Life [1]Introductory Booklet by the US Department of Health and Human Services