WikiJournal Preprints/Potential Of Cassava Leaf Extract (Manihot esculenta Crantz.) In Reducing Of Chronic Inflammatory Cells In Rats Liver Peridontitis Model

WikiJournal Preprints
Open access • Publication charge free • Public peer review

WikiJournal User Group is a publishing group of open-access, free-to-publish, Wikipedia-integrated academic journals. <seo title=" Wikiversity Journal User Group, WikiJournal Free to publish, Open access, Open-access, Non-profit, online journal, Public peer review "/>

<meta name='citation_doi' value=>

Article information

Abstract

Background: Periodontitis is an inflammation of the teeth supporting tissues

with a high prevalence in Indonesia caused by Porphyromonas gingivalis. P.gingivalis is a periodontal pathogen often associated with systemic disorders. P. gingivalis and its products carried by the systemic circulation to reach the liver will trigger the inflammatory process and cause inflammatory cell infiltration. Continuous inflammation can eventually lead to chronic liver injury. Periodontitis treatment can be done by giving metronidazole. However, it comes with side effects. One alternative natural plant that provides antibacterial and anti-inflammatory effects is cassava leaves. Objective: To determine the potential of cassava leaf extract (Manihot esculenta Crantz.) in reducing the number of chronic inflammatory cells in the liver of periodontitis rat models. Research methods: This research is an experimental laboratory with a posttest-only control group design. The research sample was male Wistar rats divided into four groups: baseline, periodontitis group which was given aquadest, metronidazole, and cassava leaf extract. A rat model of P. gingivalis was induced with periodontitis. The rats were then euthanized, their livers were taken, and histological preparations were made with HE staining. Observation and counting of chronic inflammatory cells were performed around the central vein. The one-way ANOVA test was carried out based on the data from the research. Results: The results of the LSD test with a significance value of p<0.05 showed a significant difference between the baseline group and the treatment group. There was no significant difference between the extract group and the positive control group and between the extract group and the negative control group.


Main edit

article submitted as PDF

Additional information edit

Acknowledgements edit

Any people, organisations, or funding sources that you would like to thank.

Competing interests edit

Any conflicts of interest that you would like to declare. Otherwise, a statement that the authors have no competing interest.

Ethics statement edit

An ethics statement, if appropriate, on any animal or human research performed should be included here or in the methods section.

References edit