Motivation and emotion/Book/2021/Psychedelics and higher selves

Psychedelics and consciousness:
How can altered consciousness be used to facilitate personal growth?

Since the usage of peyote and psilocybin in Shamanic ceremonies to a tab of acid placed on someone's tongue at a party; psychedelics have always been a controversy in the medicinal field. As we progress further into the 21st century, there's been a paradigm shift within the psychopharmacological community towards the use of psychedelics for therapy.

We shall explore the usage of psychedelics as facilitators of growth.

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Historical usage of psychedelics edit

5000 BC - Early evidence in the Tassili n' Ajjer Plateau edit

  •  
    Fig 1. Artistic representation of Tassili n ' Ajjer rock paintings
    Rock paintings of mushroom-holding Shamans
  • Could symbolize a lost religion based on hallucinogenic mushrooms


Peyote in Native American tribes edit

  • Found in the Shumla cave no.5 on the Rio Grande, Texas dating back to 3780-3660 BC
  • Alkaloid extraction led to identification of mescaline in two samples


Mysteries of Soma and Kykeon edit

  • Ancient psychedelic drink called Soma was mentioned in the Rig Veda
  • Use of ergot in brewing the potion called Kykeon in the Greek Elusinian Mysteries
  • Ergot also used to synthesise LSD

  Interesting fact: Ergot is a fungus that grows on the seeds of rye/morning glory. Psilocybin, the psychoactive substance within 'magic mushrooms' has a similar chemical structure to ergot.

Stoned ape theory edit

Entheogenic origins of consciousness edit

  •  
    Figure 2. The evolution of the brain from apes to humans
    File:Stoned ape.jpg
    Fig 2. Stoned ape
    Terrence McKenna's argument on consciousness and language being emergent properties through the consumption of psilocybin by Homo erectus
  • Entheogenic origins of consciousness common around many indigenous tribes

Criticism edit

  • Carhart-Harris states that psilocybin inhibits the activity in areas of the human brain that are involved in cognitive and symbolic changes
  • No evidence of Psylocybin cubensis mushrooms a million years ago in the sub-Saharan dessert

Entropic brain hypothesis

  • How it ties into the stoned ape theory and the expansion of the mind just between the "tipping point" of order and chaos

Shamanic roots of psychedelics edit

Traditional ceremonies edit

  • Entheogenic/psychoactive compounds such as peyote, psilocybe mushrooms, iboga, and their significance with shamanic ceremonies
  • Role of curandera or healer

Current clinical studies on shamanistic rituals edit

  • Perception of non-material spirits or entities and access to hidden knowledge - significance in self development

Psilocybin edit

 
Fig 3. Metabolism of psilocybin

Mechanism of activating 5-HT2A receptors in prefrontal cortex edit

  • Metabolism of psilocybin to psilocin
  • Increased neural connectivity and deactivation of default mode network




Therapeutic usage of psilocybin edit

  • Treatment of depression through clinical administration of psilocybin
  • Treatment of opioid, alcohol and nicotine addiction





Limitations of studies edit

  • Self reported cross-sectional studies don't provide concrete causal inferences

Ayahuasca and DMT edit

 
Fig 5. 2D Structure of N,N-Dimethyltryptamine

N,N- Dimethyltryptamine edit

  • Indole alkaloid found in plants and animals
  • Released during birth and death - implications?
  • Shortest but most intense psychedelic experience

Ayahuasca in indigenous ceremonies edit

  • Amazonian origins
 
Fig 6. Brewing of ayahuasca
  • Decoction prepared from Banisteriopsis caapi and Psychotria viridis, importance of dieta
  • Qualitative field studies conducted in Peru on overcoming substance abuse
  • Changes in neuroticism (Weiss, B., Miller, J. D., Carter, N. T., & Keith Campbell, W.,2021)



Lysergic Acid Diethylamide (LSD) edit

  •  
    Fig 7. LSD molecular structure
    Similar effects to psilocybin on 5HT2A receptors (Dolder, P. C., Schmid, Y., Müller, F., Borgwardt, S., & Liechti, M. E., 2016)

Effects on cognition and emotions edit

  • Impairment of recognising negative emotions and increased empathy
  • Increase of fractal dimensions in temporal and spatial domains

1 Ayahuasca contains ergot:

True
False

2 Psilocybin affects the reuptake of serotonin:

True
False


Studies on psychedelic-assisted therapy edit

Increasing prominence of 3,4-Methylenedioxymethamphetamine (MDMA) edit

  • Mood elevating effects
  • Treatment of depression and PTSD

Ketamine edit

Psilocybin edit

Altered states of consciousness and the self edit

  • Connection to a larger collective consciousness
  • Implications for fostering a sense of community and wellbeing


See also edit

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References edit

Loizaga-Velder, A., & Verres, R. (2014). Therapeutic Effects of Ritual Ayahuasca Use in the Treatment of Substance Dependence—Qualitative Results. Journal of Psychoactive Drugs, 46(1), 63–72. https://doi-org.ezproxy.canberra.edu.au/10.1080/02791072.2013.873157

  Carhart-Harris, R. L., Leech, R., Hellyer, P. J., Shanahan, M., Feilding, A., Tagliazucchi, E., Chialvo, D. R., & Nutt, D. (2014). The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs. Frontiers in Human Neuroscience, 8, 20–20. https://doi.org/10.3389/fnhum.2014.00020

 Lebedev, A. V., Lövdén, M., Rosenthal, G., Feilding, A., Nutt, D. J., & Carhart-Harris, R. L. (2015). Finding the self by losing the self: Neural correlates of ego-dissolution under psilocybin. Human Brain Mapping, 36(8), 3137–3153. https://doi.org/10.1002/hbm.22833


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