Motivation and emotion/Book/2021/Psilocybin assisted psychotherapy

Psilocybin assisted psychotherapy:
How can psilocybin be used to assist psychotherapy?

Multimedia presentation (3 min)

OverviewEdit

Overview of protocols for psilocybin assisted psychotherapy across patient cohorts.

case studies

supplementation with omega 3 for enhanced neurogenesis and lasting neurological change.

integration strategies

Focus questions:

Why use psylocybin in therapy?
How to get the most out of a psylocybin assisted session?
What is integration?

What does psilocybin do?Edit

How does psilocybin impact neurological connections
what is the theraputic impact of this change
why is it helpful in a clinical setting

Communication between brain networks in people given psilocybin (right) or a non-psychedelic compound (left).

Psilocybin is a serotonergic psychedelic with untapped therapeutic potential. There are hints that the use of psychedelics can produce neural adaptations, although the extent and timescale of the impact in a mammalian brain are unknown. In this study, we used chronic two-photon microscopy to image longitudinally the apical dendritic spines of layer 5 pyramidal neurons in the mouse medial frontal cortex. We found that a single dose of psilocybin led to ∼10% increases in spine size and density, driven by an elevated spine formation rate. The structural remodeling occurred quickly within 24 h and was persistent 1 month later. Psilocybin also ameliorated stress-related behavioral deficit and elevated excitatory neurotransmission. Overall, the results demonstrate that psilocybin-evoked synaptic rewiring in the cortex is fast and enduring, potentially providing a structural trace for long-term integration of experiences and lasting beneficial actions.

Psilocybin assisted therapy protocolsEdit

Describe hopkins protocols

How to prepare for a psilocybin assisted sessionEdit

Two weeks before the session
one week before the sesion
Day of the session

The reduction in stroke-induced neurological deficits with n-3 PUFA post-treatment was associated with enhanced angiogenesis, oligodendrogenesis, neuron survival and white matter restoration. Together, these results indicate that the neurological benefits of n-3 PUFA administration after stroke extend to older animals and are associated with improved neuronal survival and brain remodeling, therefore suggesting that post-stroke administration of n-3 PUFAs is a viable clinically relevant treatment option against stroke.

What is integration and why is it important?Edit

What is post session integration
why is integration important
Integration activities

ConclusionEdit

ReferencesEdit

Aday, J.S., Davis, A.K., Mitzkovitz, C.M., Bloesch, E.M., & Davoli, C.C. (2021). Predicting reactions to psychedelic drugs: a systematic review of states and traits related to acute drug effects. ACS Pharmacology & Translational Science, 4(2), 424–435. https://pubs.acs.org/doi/10.1021/acsptsci.1c00014

Fleischmann, C., Shohami, E., Trembovler, V., Heled, Y,. & Horowitz, M. (2020) Cognitive Effects of Astaxanthin Pretreatment on Recovery From Traumatic Brain Injury. Frontiers in Neurology. (11) https://doi.org/10.3389/fneur.2020.00999

Garcia-Romeu, A., Barrett, F.S., Carbonaro, T.M., Johnson, M.W., & Griffiths, R.R. (2021). Optimal dosing for psilocybin pharmacotherapy: Considering weight-adjusted and fixed dosing approaches. Journal of Psychopharmacology, 35(4), 353-361.https://journals.sagepub.com/doi/full/10.1177/0269881121991822

Jiang X, Suenaga J, Pu H, Wei Z, Smith AD, Hu X, Shi Y, Chen J. Post-stroke administration of omega-3 polyunsaturated fatty acids promotes neurovascular restoration after ischemic stroke in mice: Efficacy declines with aging. Neurobiol Dis. 2019 Jun;126:62-75. doi: 10.1016/j.nbd.2018.09.012. Epub 2018 Sep 12. PMID: 30218758.

Petri, G., Expert, P. , Turkheimer, F. , Carhart-Harris, R., Nutt, D. , Hellyer, P. J. & Vaccarino, F. (2014). Homological scaffolds of brain functional networks. Journal of The Royal Society Interface, https://royalsocietypublishing.org/doi/abs/10.1098/rsif.2014.0873

Strickland, J.C., Garcia-Romeu, A., & Johnson, M.W. (2021). Set and setting: a randomized study of different musical genres in supporting psychedelic therapy. ACS Pharmacology & Translational Science, 4(2), 472-478. https://pubs.acs.org/doi/full/10.1021/acsptsci.0c00187

Shao LX, Liao C, Gregg I, Davoudian PA, Savalia NK, Delagarza K, Kwan AC. Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo. Neuron. 2021 Aug 18;109(16):2535-2544.e4. doi: 10.1016/j.neuron.2021.06.008. Epub 2021 Jul 5. PMID: 34228959; PMCID: PMC8376772.

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