Downstream promoter elements is a lecture and an article from the biochemistry department and the genetics department. It is also part of the original research gene project.

The diagram is an overview of four core promoter elements. Credit: Jennifer E.F. Butler & James T. Kadonaga.

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Quiz edit


1 Yes or No, DPE-dependent basal transcription depends highly on the Inr (and vice versa) and on correct spacing between the two elements.


2 Yes or No, The core sequence of the DPE is located at precisely +28 to +32 relative to the A+1 nucleotide.


3 Yes or No, The core promoter elements such as DPE are trans acting elements.


4 Several promoter elements have been previously identified in eukaryotes, but those cannot account for transcription from most RNA polymerase II-transcribed

5 True or False, The downstream promoter element is located in the distal promoter.


6 Which of the following is not a transcriptional characteristic of the downstream promoter element?

located between nucleotides -8 and +2 relative to the transcriptional start site (+1)
in eukaryotes
TATA-less genes
a consensus sequence

7 True or False, The downstream promoter element is upstream by about +40 nucleotides.


8 Which of the following are phenomena associated with the downstream promoter element?

transcription of A1BG
directs activator-dependent but TFIID-independent transcription
TATA box-less promoters
transcription start site
mediator dependence
core promoter
RNA polymerase II holoenzyme

9 True or False, The downstream promoter element is found in the promoter regions of about 1% of human genes.


10 True or False, The downstream promoter element is most likely to occur with the Inr.


Hypotheses edit

  1. The downstream promoter elements are not involved in the transcription of A1BG.

See also edit

External links edit

{{Anthropology resources}}

{{Medicine resources}}{{Phosphate biochemistry}}