Downstream TFIIB recognition element is a lecture as part of the gene transcription series.

This diagram indicates the components of a nucleotide. Credit: Calibuon.

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Quiz edit


1 Yes or No, A TFIIB recognition element (BRE) functions to determine the orientation of the TFIIB-TBP-TATA complex that projects the zinc ribbon of TFIIB toward the TSS.


2 The portion of the promoter in which a distal promoter is likely to be found is which of the following?

dispersed promoter
proximal promoter
downstream promoter
distant promoter
focused promoter

3 Yes or No, The TFIIB-DNA contact with the BREd takes place via the minor groove, while that with the upstream B recognition element (BREu) takes place through the major groove.


4 Several promoter elements have been previously identified in eukaryotes, but those cannot account for transcription from most RNA polymerase II-transcribed

5 Yes or No, Some distal promoters are located in the dispersed promoter.


6 Which of the following is not a transcriptional characteristic of distal promoters?

located between nucleotides -8 and +2 relative to the transcriptional start site (+1)
in eukaryotes
TATA-less genes
a consensus sequence

7 Complete the text:

A distal promoter is a

(in numbers of nucleotides) portion of the

for a particular


8 Complete the text:

Match up the type of promoter or promoter element with each of the possibilities below:
TATA box - A
initiator element - B
enhancers and inhibitors - C
downstream elements - D
General transcription factor II D - E
ATA box - F
downstream core promoter

includes the transcription start site

proximal promoter

distal promoter

core promoter

usually 25 nucleotides upstream


9 Which of the following are phenomena associated with downstream TFIIB recognition elements?

transcription of A1BG
directs activator-dependent but TFIID-independent transcription
TATA box-less promoters
initiator element
mediator dependence
proximal promoter

10 True or False, Downstream TFIIB recognition elements are found in the promoter regions of at least 1% of human genes.


Hypotheses edit

  1. A1BG is not transcribed by a downstream TFIIB recognition element.

See also edit

External links edit

{{Anthropology resources}}

{{Medicine resources}}{{Phosphate biochemistry}}