Talk:Progress and Prospects in Parkinson's Research/Hot Topics

I suggest we start a list of topics here that could be elaborated into Hot Topics.
Topic Example Instances Links
Genetics
23&Me http://www.capradio.org/news/npr/story?storyid=158943097
Mennonite gene DNAJC13 http://www.sciencedaily.com/releases/2012/06/120627131936.htm, http://www.sciencecodex.com/parkinsons_disease_gene_identified_with_help_of_mennonite_family_ubcvch_research-94062
FOXO1 http://www.sciencedaily.com/releases/2012/06/120629142609.htm, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386245/
LRRK2 http://medicalxpress.com/news/2012-05-blocking-lrrk2-simple-parkinson-disease.html, http://www.molecularneurodegeneration.com/content/pdf/1750-1326-7-25.pdf
Non-notor
Existing drugs
Apomorphine
Ropinirole implants http://www.marketwatch.com/story/titan-completes-preclinical-study-of-a-continuous-dopamine-agonist-treatment-for-parkinsons-disease-2012-07-09
Inhaled levodopa phase 2 http://www.marketwatch.com/story/civitas-therapeutics-initiates-phase-2a-clinical-study-of-cvt-301-an-inhaled-l-dopa-for-parkinsons-disease-2012-06-15
Latrepirdine http://www.ncbi.nlm.nih.gov/pubmed/22869031
Caffeine http://www.cbsnews.com/8301-504763_162-57484791-10391704/caffeine-from-two-to-four-daily-cups-of-coffee-may-reduce-parkinsons-disease-symptoms/
Anti-inflammatories
anti-cytokines http://www.jneurosci.org/content/32/30/10201.abstract?sid=864d8c7c-49b2-416d-996d-bc668e978038
Triterpenoids boost Nrf2 http://www.sciencedaily.com/releases/2012/07/120723134755.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed:+sciencedaily/health_medicine/parkinsons_disease+(ScienceDaily:+Health+&+Medicine+News+--+Parkinson's+Research), http://www.ncbi.nlm.nih.gov/pubmed/22746536
Risk factors for PD
Family member http://www.familypracticenews.com/news/more-top-news/single-view/family-history-tops-parkinson-s-disease-risk-factors/46665e2ae4daab3b55054aa8e8d65106.html
Flu http://india.nydailynews.com/business/9b1d626c4fd9d5c80501387b88098d07/severe-flu-doubles-odds-of-developing-parkinson-s, http://india.nydailynews.com/business/9b1d626c4fd9d5c80501387b88098d07/severe-flu-doubles-odds-of-developing-parkinson-s
Diagnosis, biomarkers
Alpha-Synuclein
iPSCs
Neuroprotection
XP23829, a fumaric acid ester http://www.marketwatch.com/story/xenoport-awarded-grant-from-the-michael-j-fox-foundation-to-examine-xp23829-in-preclinical-models-of-parkinsons-disease-2012-07-11
isradipine https://foxtrialfinder.michaeljfox.org/newsletter/1/#1
rapamycin http://www.sciencedaily.com/releases/2012/06/120629211902.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed:+sciencedaily/mind_brain/neuroscience+(ScienceDaily:+Mind+&+Brain+News+--+Neuroscience),http://www.ncbi.nlm.nih.gov/pubmed/22750207
DBS and rTMS
DBS Long term benefits http://www.webmd.com/parkinsons-disease/news/20120620/device-calms-parkinsons-tremor-3-years
rTMS http://www.sciencealert.com.au/news/20121107-23561.html, http://www.ncbi.nlm.nih.gov/pubmed/22881826
Open Access to publicly funded research results http://www.guardian.co.uk/science/2012/jul/15/free-access-british-scientific-research
Example Example Example


Droflet (talk) 10:52, 28 May 2012 (UTC)Reply

What do we Know? (Suggestions for Hot Topics)

edit

The following was added to the resource page by ‎User:Reverett123. I have moved them here and shall explain the reasons for doing this and give as much help as possible on his/her talk page at User_talk:Reverett123

Droflet (talk) 11:45, 6 October 2012 (UTC)Reply

. What Do We Know?

II. Systems Interacting in Parkinson’s Disease

A. Immune System B. Endocrine System C. Gastrointestinal System D. Central Nervous System E. Neurotransmitters, Hormones, and Cytokines

III. The Path of Progression of PD

A. Predisposing Factors B. Initiating Triggers

IV. Ongoing Processes

A. Oxidation B. Excitotoxicity C. Mitochondrial Failure D. Neuronflammation and Microglia E. Stress and the HPA F. Autoimmunity

V. Time Periods Related to PD

A. Preconception B. Prenatal C. Prepuberty D. Puberty E. Young Adult F. Mid-Life G. Senior


VI. External Factors and PD

A. Lipopolysaccharide (LPS) B. Pathogens C. Ultrafine Particulates D. Toxins E. Epigenetics

VII. Internal Factors and PD

A. Alpha-Synuclein B. Blood Brain Barrier C. Circadian Rhythms D. Constipation E. Electrolytes and Ion Channels F. Genetics G. Metabolic Factors and Nutrition

VIII. Treatment, Repair, and Cure

A. Therapeutics B. Neurogenesis C. Symptoms

IX. Miscellany

A. Historical View of PD B. Homeostasis C. Related Disorders D. Rhythmic Disruption

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