Open Pathology Project/Atherosclerosis

Atherosclerosis is a disease in which the walls of the arteries develop lesions due to the buildup of fats and other substances. Despite the systemic risk factors of this disease (ie. high blood pressure, high blood cholesterol, and smoking) these lesions form at regions within the vasculature that experience blood flow profiles that are non-laminar[1].

Atherosclerosis showing extracellular lipid accumulation and foam cells.

More information edit

  1. Chiu, Jeng-Jiann; Chien, Shu (2011-01). "Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives". Physiological Reviews 91 (1): 327–387. doi:10.1152/physrev.00047.2009. ISSN 1522-1210. PMID 21248169. PMC 3844671.