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This page lists current researches in developing cures and therapies for different pathologies.

The goal of this page is to be a tool see the current state of each research, how it's progressing or if it had failed.

Please help expand it!

Diabetes type 1 edit

  • Cell Based Therapeutics[1]

Diabetes type 2 edit

Kidney failure edit

  • Growing a Kidney In-Situ / De novo organogenesis[2]
  • Cell Transplantation[2]
  • Growing a Kidney In-Vitro[2]
  • Reseeding a Kidney: Decellularized Scaffolds[2]
  • Bioengineering a Kidney[2]
  • Bioartificial Renal Epithelial Cell System (BRECS)[2]
  • Implantable Renal Assist Device (iRAD)[2] / implantable bioartificial kidney (BAK)[3]

Cancer edit

Crohn's disease edit

Major Depressive Disorder edit

Inflammation-related depression edit

Studies shows for an elevated cytokines in depressed patients: IL-1β, IL-6, sIL-2R (soluble IL-2 receptors) and TNF-α [7] and those cytokines may reduce monoamine levels.[8]

Konsman present an important critical review paper on the subject.[9]

  • Anti-inflammatory Treatment[10]

See Also edit

References edit

  1. Zamboni, Fernanda; Collins, Maurice N. (2017-4). "Cell based therapeutics in type 1 diabetes mellitus". International Journal of Pharmaceutics (Elsevier) 521 (1-2): 346–356. doi:10.1016/j.ijpharm.2017.02.063. ISSN 0378-5173. PMID 28242376. 
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Kim, S; Fissell, WH; Humes, DH; Roy, S (2015). "Current strategies and challenges in engineering a bioartificial kidney". Frontiers in bioscience (Elite edition) 7: 215-228. 2015-01-01. ISSN 1945-0494. PMID 25553375. PMC PMC4383659. // 
  3. Humes, HD; Buffington, D; Westover, AJ; Roy, S; Fissell, WH (March 2014). "The bioartificial kidney: current status and future promise". Pediatric Nephrology 29 (3): 343–351. doi:10.1007/s00467-013-2467-y. ISSN 0931-041X. 
  4. Kast, RE; Altschuler, EL (Nov 2001). "Remission of Crohn's disease on bupropion". Gastroenterology (Elsevier) 121 (5): 1260–1261. doi:10.1053/gast.2001.29467. ISSN 0016-5085. PMID 11706830. 
  5. Mosaic, LS. "Why a third of antidepressants are prescribed for something else". CNN. Retrieved 2019-07-06.
  6. Brustolim, D; Ribeiro-dos-Santos, R; Kast, RE; Altschuler, EL; Soares, MBP (Jun 2006). "A new chapter opens in anti-inflammatory treatments:The antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice". International Immunopharmacology (Elsevier) 6 (6): 903–907. doi:10.1016/j.intimp.2005.12.007. ISSN 1567-5769. PMID 16644475. 
  7. Liu, Yang; Ho, Roger Chun-Man; Mak, Anselm (2012-8). "Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression". Journal of Affective Disorders 139 (3): 230–239. doi:10.1016/j.jad.2011.08.003. ISSN 1573-2517. PMID 21872339. 
  8. Yang, Longfei; Zhao, Yinghao; Wang, Yicun; Liu, Lei; Zhang, Xingyi; Li, Bingjin; Cui, Ranji (2015-08-31). "The Effects of Psychological Stress on Depression". Current Neuropharmacology 13 (4): 494–504. doi:10.2174/1570159x1304150831150507. PMID 26412069. PMC PMC4790405. 
  9. Konsman, JP (2019-02-14). "Inflammation and Depression: A Nervous Plea for Psychiatry to Not Become Immune to Interpretation". Pharmaceuticals 12 (1). doi:10.3390/ph12010029. ISSN 1424-8247. PMID 30769887. PMC 6469164. 
  10. Kopschina Feltes, Paula; Doorduin, Janine; Klein, Hans C; Juárez-Orozco, Luis Eduardo; Dierckx, Rudi AJO; Moriguchi-Jeckel, Cristina M; de Vries, Erik FJ (2017-9). "Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy". Journal of Psychopharmacology (Oxford, England) 31 (9): 1149–1165. doi:10.1177/0269881117711708. ISSN 0269-8811. PMID 28653857. PMC 5606303.