Introduction to Parkinson's Science/Q Page 1

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If you or someone close to you is diagnosed with Parkinson's it is likely to be a shock.

It is something you have to come to terms with and to help you with this you are very likely to want some questions answered.

Your physician or neurologist is likely to provide the answers to to certain basic questions. But then more will arise in your mind that were not answered at the initial consultation.

What do you want to know?

There are many organisations which have put basic information about Parkinson's on their web sites. Here are some:

• Parkinson's UK
• Michael J Fox Foundation
• Parkinson's Movement
• Northwest Parkinson's Foundation
• European Parkinson's Disease Association

There is no need to replicate all that information here, but here is a summary of the answers to some of the immediate questions people often have.

Subsequent pages will deal with the answers to more probing questions.

On each page hyperlinks in the topic boxes on the right will give further detailed information on terms and concepts as they arise.

What has caused me to have Parkinson's?

In most cases the cause of a person's Parkinson's is unknown. That is why it is called idiopathic or sporadic. For a minority there is a genetic link ('familial' Parkinson's) but even here there may not be evidence that it 'runs in the family'.

There are a number of external factors that have been linked to Parkinson's and these are given in the Section 1 topic of Parkinson's Causes. Usually there is no way of knowing whether any one of these in particular has caused an individual to contract the disease. It is thought that idiopathic Parkinson's disease is in most cases likely to be due to a combination of environmental and genetic factors.

Does Parkinson's reduce life expectancy?

Parkinson's is rarely put down as the primary cause of death. Usually the death of a person with Parkinson's is the result of some other condition but Parkinson's may contribute to a shortening of life. In a booklet titled Parkinson's and You published by Parkinson's UK it is put this way:

For the majority of people, Parkinson’s will not affect their life expectancy. However, some of the more advanced symptoms can lead to increased disability and poor health, which can make someone more vulnerable to infection.

Is Parkinson's contagious?

No.

What are the usual early symptoms and what confirms the diagnosis?

The first symptoms displayed by a person diagnosed with Parkinson's are likely to include tremor, stiffness, slowness of movement and problems with posture and balance. (Often tremor is not one of the presenting symptoms.)

These will suggest to the neurologist that it is likely to be Parkinson's but there are a number of other tests that the neurologist will performed during an examination to help with diagnosis. There is no definitive test for confirming Parkinson's.

It is often difficult, especially in the early stages, to differentiate between Parkinson's and other Parkinsonian syndromes such as MSA and PSP.

There is a lot of information on the internet about diagnosing Parkinson's including this information sheet by Parkinson's UK. See also ref for a clear description.

How will the disease progress?

Parkinson's is a progressive neurological disease for which there is currently no cure. Over time the movement difficulties will get worse (although medication can effect a satisfactory improvement at first). Eventually symptoms like a pronounced stoop, reduced facial expression (Parkinson's mask) and difficulty in initiating movement (freezing) are likely to occur and other symptoms which are often not realised to be part of the disease such as constipation, bladder problems, depression, handwriting problems, and speech and swallowing difficulties become more troublesome. Some side effects of the medication can occur (such as involuntary movements known as dyskinesia and obsessive-compulsive disorders). The more advanced stages of Parkinson's often involve cognitive problems. A person with Parkinson's can, however, expect an reasonable quality of life over very many years.

Follow-up questions What causes the motor symptoms? The lack of dopamine and what this brain chemical does Why is there not enough dopamine? Death of cells in a region of the brain called the substantia nigra What treatment can be given? An overview of the drugs and other therapies that can be used to treat Parkinson's

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Browse all questions and answers in Section 2: An Introduction to Parkinson's Science All Section 2 sub_pages

Site Map

Background information Wikipedia entry on Parkinson's disease Causes of Parkinson's Diagnosing Parkinson's The Parkinson's UK Brain Bank diagnostic criteria Early symptoms How Parkinson's progresses Parkinson's Disease Foundation -progression Assesssment of the stage of Parkinson's Hoehn and Yahr scale Unified Parkinson's Disease Rating Scale (UPDRS)

Other related background topics Braak Staging hypothesis Diagnosis and Management of Parkinson's NICE Guidelines All Parkinson's Symptoms

What you can do Please Login first. (Create an account if you have not got one yet.) Add a topic or question Go to the Section 2 Site Map. See if your topic or question is already there. If so, add or expand an answer If not, add your topic or question by following the instructions on that Site Map subpage. Any part of this wikiversity project can be worked on by anyone. If there is something that is missing or needs further elaboration, then just add it! (Please back up all the assertions you make with references to external sources.) Discuss changes and ask questions Use the Discussion tab at the top of the page if you want to discuss possible changes in advance, make suggestions, ask questions that others might answer or ask other people's opinions. Parkinson's Science project User Guide

References