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Summary
DescriptionO. tsutsugamushi in U937 cells.tif
English: Transmission electron microscopy of O. tsutsugamushi in human (U937) cells. Panel A: Bacterial cells with corners and tent-like stretching within the cytoplasm with adjacent mitochondria (Mi). Bar length corresponds to 1 µm. Panel B: A number of O. tsutsugamushi (B) with associated microparticles (arrowheads) within the host cell cytoplasm. Bar represents 500 nm. Panel C: Enlargement of the enclosed bacterium from Panel B showing blebbing of the outer membrane (arrow). ‘mp’ - detached microparticle. Bar length corresponds to 100 nm. Panel D: Detail of two microparticles (mp) formed by the outer, but not inner leaflet of O. tsutsugamushi. These microparticles carry the surface antigens of the ‘mother’ Orientia, and their function remains unclear. Bar length corresponds to 100 nm. Insert - Enlargement of the enclosed area in D showing the structure of the limiting membrane of the microparticle. Bar length corresponds to 10 nm.
Date
Source
Orientia tsutsugamushi in Human Scrub Typhus Eschars Shows Tropism for Dendritic Cells and Monocytes Rather than Endothelium. PLoS Negl Trop Dis 6(1): e1466. (2012) https://doi.org/10.1371/journal.pntd.0001466
Author
Paris DH, Phetsouvanh R, Tanganuchitcharnchai A, Jones M, Jenjaroen K, Vongsouvath M
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